
Hao Lab
-EST. 2024-
Exploring, Discovering, Revolutionizing — Next-Gen Therapeutics

37. In-situ engineering of native extracellular matrix for therapeutic revascularization in ischemic tissue injury
D Hao*, L Lu, R Liu, J Lopez, J Nolta, D Farmer, K Lam, A Panitch, A Wang*. Med-X. 2024, 2 (1): 19.
*Co-corresponding author.
36. A bio-instructive parylene-based conformal coating suppresses thrombosis and intimal hyperplasia of prosthetic vascular devices
D Hao, J Lin, R Liu, C Pivetti, K Yamashiro, L Schutzman, N Bahatyrevich, J Sageshima, M Kwong, D Farmer, M Humphries, A Panitch, K Lam, A Wang. Bioactive Materials. 2023, 28: 467-479.
35. A bioactive material with dual integrin-targeting ligands regulates specific endogenous cell adhesion and promotes vascularized bone regeneration in adult and fetal bone defects
D Hao, R Liu, T Fernandez, C Pivetti, J Jackson, E Kulubya, H Jiang, H Ju, W Liu, A Panitch, K Lam, K Leach, D Farmer, A Wang. Bioactive Materials. 2023, 20: 179-193.
34. A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling
A Stahl#, D Hao#, J Barrera, D Henn, S Lin, S Moeinzadeh, S Kim, W Maloney, G Gurtner, A Wang, Y Yang. Bioactive Materials. 2023, 19: 167-178. #Co-first author.
33. Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair
D Hao, L Lu, H Song, Y Duan, J Chen, R Carney, J Li, P Zhou, J Nolta, K Lam, K Leach, D Farmer, A Panitch, A Wang. Theranostics. 2022, 12(13):6021-6037.
32. Engineering extracellular microenvironment for tissue regeneration
D Hao, J Lopez, J Chen, A Iavorovschi, N Lelivelt, A Wang. Bioengineering. 2022, 9 (5): 202.
31. Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells
D Hao, Y Fan, W Xiao, R Liu, C Pivetti, T Walimbe, F Guo, X Zhang, D Farmer, F Wang, A, K Lam, A Wang. Acta Biomaterialia. 2020, 108: 178-193.
30.Enhanced cytocompatibility of Poly(lactic acid)/Polycaprolactone membrane via integrin-based peptide targeting human chorionic villus derived mesenchymal stem cells for fetal tissue engineering
D Hao, C He, B Ma, R Liu, K Lam, D Farmer, A Wang. Journal of Materials Chemistry B. 2020, 8 (8): 1649-1659.
29. Developing an injectable nanofibrous extracellular matrix hydrogel with an integrin αvβ3 ligand to improve endothelial cell survival, engraftment and vascularization
D Hao, R Liu, K Gao, C He, S He, C Zhao, G Sun, D Farmer, A Panitch, K Lam, A Wang. Frontiers in Bioengineering and Biotechnology. 2020, 8: 890.
28. Extracellular matrix mimicking nanofibrous scaffolds modified with mesenchymal stem cell-derived extracellular vesicles for improved vascularization
D Hao, H Swindell, L Ramasubramanian, R Liu, K Lam, D Farmer, A Wang. Frontiers in Bioengineering and Biotechnology. 2020, 8: 633.
27. Hypoxic preconditioning increases survival and pro-angiogenic capacity of human chorionic villus derived mesenchymal stem cells
D Hao, B Ma, C He, L Lankford, D Farmer, A Wang. Stem Cells International. 2019, 11 (12): 9695239.
26. Discovery and characterization of a potent and specific peptide ligand targeting endothelial progenitor cells and endothelial cells for tissue regeneration
D Hao, W Xiao, R Liu, P Kumar, Y Li, P Zhou, F Guo, D Farmer, K Lam, F Wang, A Wang. ACS Chemical Biology. 2017, 12(4): 1075-1086.
25. Prosthesis Embodiment in Lower Extremity Limb Loss: A Narrative Review
T Nguyen, B Wang, H Alas, Q Jones, C Clark, D Hao, A Li. Prosthesis Embodiment in Lower Extremity Limb Loss: A Narrative Review. Applied Sciences. 2025, 15(9): 4952.
24. FTO-mediated m6A demethylation of SERPINE1 mRNA promotes tumor progression in hypopharyngeal squamous cell carcinoma
N Sa, X Liu, D Hao, Z Lv, S Zhou, L Yang, S Jiang, J Tian, W Xu. Translational Cancer Research. 2025, 14(1): 595-612.
23. Development of pro-angiogenic skin substitutes for wound healing. Wound Repair and Regeneration
H Song, D Hao, J Zhou, D Farmer, A Wang. Wound Repair and Regeneration. 2024. DOI: 10.1111/wrr.13154.
22. Engineered multi-functional, pro-angiogenic collagen-based scaffolds loaded with endothelial cells promote large deep burn wound healing
H Song, K Gao, D Hao, A Li, R Liu, B Anggito, B Yin, Q Jin, K Lam, L Smith, V Dartora, A Panitch, D Farmer, A Wang. Frontiers in Pharmacology. 2023, 14: 481.
21. Evaluation of a biodegradable polyurethane patch for repair of diaphragmatic hernia in a rat model: a pilot study
CTheodorou, A Taylor, S Lee, L Cortez, H Fu, C Pivetti, C Zhang, A Stasyuk, D Hao, P Kumar, D Farmer, J Liao, E Brown, Y Hong, A Wang. Journal of Pediatric Surgery, 2023. S0022-3468(23)00055-6.
20. Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing
S He, T Walimbe, H Chen, K Gao, P Kumar, Y Wei, D Hao, R Liu, D Farmer, K Lam, J Zhou, A Panitch, A Wang. Bioactive Materials. 2022, 10: 460-473.
19. Bioengineering extracellular vesicles for the treatment of cardiovascular diseases
L Ramasubramanian, S Du, S Gidda, N Bahatyrevich, D Hao, P Kumar, A Wang. Advanced Biology. 2022, e2200087.
18. Nrf2 regulates CHI3L1 to suppress inflammation and improve post-traumatic osteoarthritis
Y Song, D Hao, H Jiang, M Huang, Q Du, Y Lin, F Liu, B Chen. Journal of Inflammation Research. 2021,14: 4079-4088.
17. The unique properties of placental mesenchymal stromal cells: a novel source of therapy for congenital and acquired spinal cord injury
E Kulubya, K Clark, D Hao, S Lazar, A Rafi, T Karnati, J Ebinu, M Zwienenberg, D Farmer, A Wang. Cells. 2021,10 (11): 2837.
16. Exosomal microRNAs from mesenchymal stem/stromal cells: biology and applications in neuroprotection
A Nasirishargh, P Kumar, L Ramasubramanian, K Clark, D Hao, S Lazar, A Wang. World journal of stem cells. 2021, 13 (7): 776.
15. Bioengineered extracellular vesicle-loaded bioscaffolds for therapeutic applications in regenerative medicine
S Lazar, S Mor, J Chen, D Hao, A Wang. Extracellular Vesicles and Circulating Nucleic Acids. 2021, 2 (2): 175-178.
14. Long non-coding RNA signatures as predictors of prognosis in thyroid cancer: a narrative review
H Zhao, C Souza, V Kumar, R Nambiar, D Hao, X Zhu, Y Luo, S Liu, L Zhang, J Zhu. Annals of Translational Medicine. 2021, 2 (9): 4.
13. Leveraging glial cells and extracellular vesicles for Alzheimer’s disease: an engineered cell-free approach for early diagnosis and treatment
S Mor, Leora Helzner, K Clark, D Wang, D Hao, A Wang. WIREs Mechanisms of Disease. 2021, e1541.
12. Developing regenerative treatments for developmental defects, injuries, and diseases by targeting extracellular matrix collagen
L Helzner, D Hao, A Wang. International Journal of Molecular Sciences. 2019, 20 (17): 4072.
11. Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood-derived endothelial colony-forming cells and placental mesenchymal stromal cells
K Gao, P Kumar, E Toledo, D Hao, L Reynaga, M Rose, C wang, D Farmer, J Nolta, J Zhou, P Zhou, A Wang. Stem Cell Research & Therapy. 2019, 10: 34.
10. ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma
Z Zhou, H Jiang, K Tu, W Yu, J Zhang, Z Hu, H Zhang, D Hao, P Huang, J Wang, A Wang, Z Xiao, C He. Journal of Experimental & Clinical Cancer Research. 2019, 38:18.
9. A novel incRNA IHS promotes tumor proliferation and metastasis in HCC by regulating the ERK- and AKT/GSK-3β-signaling pathways
Z Chen, W Yu, Q Zhou, J Zhang, H Jiang, D Hao, J Wang, Z Zhou, C He, Z Xiao. Molecular Therapy - Nucleic Acids. 2019, 16: 707-720.
8. The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems
L Lu, H Chen, D Hao, X Zhang, F Wang. Asian Journal of Pharmaceutical Sciences. 2019, 14 (6): 595-608.
7. Mesenchymal stem cell-derived exosomes: potential approaches to improve efficacy and yield for cell-free therapy
J Phan, P Kumar, D Hao, K Gao, D Farmer, A Wang. Journal of Extracellular Vesicles. 2018, 7(1): 1522236.
6. Highly efficient differentiation of endothelial cells from pluripotent stem cells requires the MAPK and the PI3K pathways
A Harding, E Toledo, N Magner, J Beegle, D Coleal-Bergum, D Hao, A Wang, J Nolta, P Zhou. Stem Cells. 2017, 35(4): 909-919.
5. Comparison and optimization of DNA extraction methods from activated sludge in wastewater of epoxy propane saponification
Y Qu, L Tian, Y Li, Q Li, J Fang, D Song, J Wang, D Hao, Z Chen. Chinese Journal of Bioprocess Engineering. 2015, 1: 42-46.
4. Optimization of fermentation conditions and properties of an exopolysaccharide from Klebsiella sp. H-207 and application in adsorption of hexavalent chromium
Q Li, Y Li, S Han, Y Liu, D Song, D Hao, J Wang, Y Qu, Y Zheng. PLoS ONE. 2013, 8(1), e53542.
3. Optimization of PHAs production by Bacillus sp. PB-3 from waste activated sludge
D Hao, Q Li, S Han, J Wang, K Gong. Chinese Journal of Bioprocess Engineering. 2012, 5: 28-33.
2. Research on the Cr (VI) absorption by activated sludge AR
Q Li, S Han, D Hao, J Wang, Y Luo, D Song, X Hu. Applied Mechanics and Materials. 2012, 10 (5), 28-33.
1. T-RFLP analysis of soil microbial community from Shandong Province for forensic science
J Wang, Y Li, Z Zhao, Q Li, D Hao, Y Qu, J Li. Advanced Materials Research. 2012, 599: 250-253.